Publications - G Berry
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Health effects of asbestos - animal experiments
The first publications [13, 14] were from one of the earliest intra-pleural inoculation experiments of rats conducted by the late Dr Christopher Wagner. The analysis [14] involved probably the earliest application of the Weibull distribution, that is the model that mesothelioma incidence increases as a power of time since exposure, to asbestos. This was followed by [18, 27] in which further experiments were analyzed and a linear dose-response relationship shown to be consistent with the mesothelioma incidence in animal experiments. The power relationship was used as a means of planning experiments in a statistical methods paper [34] and the results of the experiment are in [35]. Later inoculation experiments were reported in [51, 54].
The first inhalation experiments were reported in [32] and it was in this paper that the rapid elimination of chrysotile from the lungs was noted.
13. WAGNER, J.C. & BERRY. G. (1969). Mesotheliomas in rats following inoculation with asbestos. Br. J. Cancer, 23, 567 81.
14. BERRY, G. & WAGNER, J.C. (1969). The application of a mathematical model describing the times of occurrence of mesotheliomas in rats following inoculation with asbestos. Br. J. Cancer, 23, 582 6.
18. WAGNER, J.C., BERRY, G. & TIMBRELL, V. (1970). Mesotheliomas in rats following the intra pleural inoculation of asbestos. In: Pneumoconiosis. Proceedings of the International Conference, Johannesburg, 1969, ed. H.A. Shapiro, 216 9. Oxford University Press, Cape Town.
27. WAGNER, J.C., BERRY, G. & TIMBRELL, V. (1973). Mesotheliomata in rats after inoculation with asbestos and other materials. Br. J. Cancer, 28, 173 85.
32. WAGNER, J.C., BERRY, G., SKIDMORE, J.W. & TIMBRELL, V. (1974). The effects of the inhalation of asbestos in rats. Br. J. Cancer, 29, 252 69.
34. BERRY, G. (1975). Design of carcinogenesis experiments using the Weibull distribution. Biometrika, 62, 321 8.
35. BERRY, G. & WAGNER, J.C. (1976). Effect of age at inoculation of asbestos on occurrence of mesotheliomas in rats. Int. J. Cancer, 17, 477 83.
40. MORGAN, A., DAVIES, P., WAGNER, J.C., BERRY, G. & HOLMES, A. (1977). The biological effects of magnesium leached chrysotile asbestos. Br. J. exp. Path., 58, 465 73.
51. WAGNER, J.C., HILL, R.J., BERRY, G. & WAGNER, M.M.F. (1980). Treatments affecting the rate of asbestos induced mesotheliomas. Br. J. Cancer, 41, 918 22.
54. WAGNER, J.C., BERRY, G., SKIDMORE, J.W. & POOLEY, F.D. (1980). The comparative effects of three chrysotiles by injection and inhalation in rats. In: Biological Effects of Mineral Fibres, ed. J.C. Wagner, 363 72. IARC Scientific Publications No. 30, Lyon.
60. WAGNER, J.C., CHAMBERLAIN, M., BROWN, R.C., BERRY, G., POOLEY, F.D., DAVIES, R. & GRIFFITHS, D.M. (1982). Biological effects of tremolite. Br. J. Cancer, 45, 352 60.
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