The Effects of Marijuana and other Drugs

Use of Marijuana and other illicit drugs may play role in increase of genital abnormalities and infertile in males

Legislation Fraud: "Industrial" Hemp
Dr. Janet Lapey's Marijuana Update 1996

Do You Know This About Marijuana?

Benzopyrene. Lung cancer causing carcinogen more prevalent in marijuana than in tobacco.

Comparative analysis of mainstream smoke from marijuana and tobacco reference cigarette. A report by the National Academy of Sciences, Institute of Medicine.

Cognitive dysfunctions in chronic cannabis users observed during treatment - an integrative approach. By Thomas Lundqvist

Marijuana and tobacco comparison. Marijuana and tobacco cause at least the same amount of injury to the airways, pulmonary function, and lung immunity.

Marijuana Briefs. Medical factoids about marijuana effects.

 


USE OF MARIJUANA AND OTHER ILLICIT DRUGS MAY PLAY ROLE IN INCREASE OF GENITAL ABNORMALITIES AND INFERTILE IN MALES

A report by Auger et al., New England Journal of Medicine, 332;281-285, 1995, shows that in some countries, during the past 20 years, there was a decline in the quality of sperm of fertile men which correlated with an increase in genital abnormalities such as cancer and cryptorchidism.. This effect was independent of the age of the men. In the same issue of the New England Journal of Medicine, Howards, page 312, pointed out that male infertility is often related to lifestyle factors such as the use of marijuana, anabolic steroids, and cocaine.

COMMENTARY: While associations such as these do not prove cause and effect, it is of interest that illicit drug use could be a major factor in the decline of fertility among men over the past two decades. The authors of the original paper admit to not having another explanation and acknowledge that environmental or lifestyle factors could be playing a major role.

LOWER IQ IN TODDLERS LINKED TO PRENATAL EXPOSURE TO MARIJUANA

Researcher (Day et al, Neurotoxicology and Teratology 16;169-175, 1994), found "significant negative effects of prenatal marijuana exposure on the performance" of both African American and Caucasian children in standard intelligence tests. This negative effect on the child was related to marijuana exposure during the first and second trimester of pregnancy. On average, children exposed prenatally to marijuana will have a lower IQ compared to children who are not exposed, even when the effects of various environmental factors are adjusted for.

COMMENTARY: The children involved in this study were tracked from birth to three years. The study, which included an equal number of white and African-American women, most of whom were single and of lower socio-economic status, suggesting that marijuana, not race or other prenatal factors, accounts for these changes.

SLEEPING PROBLEMS FOUND IN TODDLERS EXPOSED TO MARIJUANA

Prenatal exposure to marijuana showed impairment in sleep pattern and more awake time after sleep onset in exposed children, at age three, compared to control children (Dahl and colleagues in the journal, Archives of Pediatric and Adolescent Medicine, 149;145-150, 1995). Sleep deprivation is frequently associated with emotional and behavioural difficulties and reduced attention span, symptoms which could be associated with other psychiatric problems as well. Marijuana directly impacts the part of the brain that regulates sleep and arousal, causing concern that prenatal use of marijuana could affect the development of that part of the brain, resulting in permanent changes in sleeping patterns.

COMMENTARY: While studies of prenatal marijuana exposure and long-term follow-up of children so exposed are rare, the weight of the evidence suggests that this exposure is not without adverse consequences for the child.

SUBSTANCE USE DURING VIETNAM ASSOCIATED WITH NINE TIMES HIGHER MORTALITY RATE THAN FOR CIVILIANS

Price et al., from Washington University School of Medicine, presented long term follow-up studies on a group of Vietnam veterans, now in their mid-40's, compared to civilian controls who did not serve in Vietnam. Veterans who tested positive for drugs upon their return from Southeast Asia, had a nine times higher death rate than that of the civilian controls. The death rate for veterans who tested negative for drugs was still four times higher. The authors concluded that substance use in the Vietnam experience played a key role in the increased mortality.

This is a culmination of a landmark study started in 1972 and consists of 900 soldiers who had come home from Vietnam the year before. All had been tested for drug use. Three year follow-up interviews were conducted in 1974 when civilian controls were also added to the sample. The current study tracks the original participants..

Available data in the present study show that a sizeable percentage of deceased veterans who tested positive for drug died of drug and/or alcohol related causes according to death certificates. Of the deceased drug positive veterans 37 percent had alcohol or drug related causes of death, and 14 percent were found to be homicide victims.

While these men tested positive in one single drug test, the authors noted that it was interesting that this one test seemed to have predicted both the high mortality and a high risk of certain causes of death. The authors noted that drug use was not the only statistically significant predictor of premature death, since veterans who tested negative for drugs still had a four times higher death rate than men of similar age and background who did not go to Vietnam.

COMMENTARY: This important study should carry major alarm messages for those who advocate casual drug use and minimise its impact on the medical and psychiatric health of the population.

TOXIC PSYCHOSIS PRODUCED BY MARIJUANA SMOKING WHILE ON ANTABUSE

A 36-year-old man who was on Antabuse for alcohol treatment smoked marijuana as a substitute for alcohol. He immediately developed an acute toxic psychosis with disorientation, lack reality, and a manic psychosis. This lasted for 48 hours. The manufacture of Antabuse have had one previous report of this type of drug interaction (Lacoursiere et al., American Journal of Psychiatry, 140;242-244, 1983.

COMMENTARY: People attesting to a relative safety of marijuana forget that there are interactions between many drugs that may lead to adverse reactions. This example of an acute toxic psychosis in someone under treatment for alcohol abuse emphasizes the potential for marijuana interactions with prescription and non-prescription substances, which could be of great danger to the patient, and of course would be unanticipated.

Drug Watch, Oregon, USA., Marijuana Research Review, Comments by William M. Bennett, M.D., Professor of Medicine, Division of Nephrology, Clinical Pharmacology and Hypertension at Oregon Health Sciences University, Portland, Oregon.

 Return To The Affects Of Marijuana Index 


LEGISLATING FRAUD: "INDUSTRIAL" HEMP

While attention has been directed to the dangerous implications of the two flawed "Medical Marijuana" initiatives passed in California and Arizona in November, 1996, another equally dangerous effort to influence public policy is underway -- and gaining steam in some parts of rural America. As one of its many strategies to soften public resolve against the legalisation of marijuana, the well-financed pro-legalisation lobby has spearheaded a movement to legalise the cultivation of marijuana under the guise of "industrial hemp." This fraud must be exposed, particularly in Illinois and other states that are targets for "industrial hemp" legislation in 1997.

Marijuana hemp is one of a number of plants commonly called hemp. It is the only hemp plant that contains psychoactive chemicals. It is the only hemp plant that is not already legal to grow. Hemp is a term applied to the woody fibre from a wide variety of plants including sisal, jute, Manila hemp, Mexican hemp, India hemp, Sunn hemp, New Zealand hemp, and even fibre from banana, pineapple, cactus and coconut fronds.

Marijuana hemp contains over 450 different chemicals, some of which are psychoactive, addictive, and dangerous. Other than for a short time during WWII, marijuana hemp cultivation has been illegal in this country since 1937.

THC, the main psychoactive ingredient in marijuana, exists in "industrial" grade marijuana at the same level as was typical of the "pot" smoked in the 1960s (1.5 - 3% THC). Today's hybrid marijuana has been known to yield in excess of 29% THC and is indistinguishable from the hemp grown for "industrial" purposes -- just as sweet corn in the fields is indistinguishable from field corn, until you bite into it!

Although today's leading agronomists and successful farmers have determined that marijuana hemp is neither a viable nor an economically feasible agricultural crop, an attempt is being made to get the support of farmers and of the American Farm Bureau for the growing of "industrial" hemp, without excluding marijuana.

Just imagine the huge government bureaucracy that would be necessary to track and make sure the allowable THC level was not violated and that the marijuana hemp crop was not diverted from its intended use!

Just imagine fields of legal marijuana blowing in the breezes, with long lines of young people volunteering to help the farmer harvest his crop!

Incredible, you say? Well consider these quotes from the "Hempsters" themselves . . .

According to an article in High Times, a pro drug magazine, a group of Americans who own a hemp emporium in Amsterdam maintain that "once the rest of the world accepts the practical uses of the cannabis plant, it's only a matter of time before they warm to the beneficent uses of smoking it as well."

The H.E.M.P. legalization lobby stands for "Help Eliminate Marijuana Prohibition."

The National Organisation for the Reform of Marijuana Laws, a pro drug legalization lobby, "is trying to educate people on the usefulness of hemp, the plant that produces marijuana," according to an article in the University of Minnesota newspaper.

An article in High Times states, "the way to legalize marijuana is to sell marijuana legally." So, some pro legalises have begun to market a variety of trendy "hemp" products, containing a variety of hemp fibres, to youth and young adults. The strategy is to represent marijuana hemp as an "industrial hemp" fibre, and thereby gain acceptance and normalcy of marijuana.

And the crowning blow comes from hempster Chris Boucher, director of The Hempstead Company in Costa Mesa, CA, owned by actor Woody Harrelson, an admitted marijuana smoker. According to an article in High Times, Boucher feels that we are near to the time when "supermarkets will sell hemp cookies and pharmacies will sell hemp medicines." Details Magazine, April 1995, reported that Harrelson was a past participant in a bong-hitting contest in Amsterdam, at which contestants suck down marijuana and hold it in their lungs for 10 seconds.

Ridiculous, you say? Well, consider that pro marijuana legalization advocate, former Colorado Senator Lloyd Casey, is reported to have said, "I would like to work with legislators as a lobbyist. I hope to get industrial hemp bills sponsored in Illinois, Indiana, Kansas, Nebraska, Ohio, South Dakota, and Washington" [in 1997].

As Janet D. Lapey, M.D., a drug prevention specialist said, "The legalization of cannabis sativa, better known as marijuana, under the guise of "industrial hemp" would result in a massive increase of psychoactive marijuana on the street with a concomitant increase in users, especially the youth."

Once again, Illinois Drug Education Alliance, Drug Watch International, and many local, state and national drug prevention organisations are ringing the alarm bell. If parents, farmers, and government officials don't heed the warning, the dangerous situations created in California and Arizona are bound to be repeated.

The bottom line is . . . Marijuana is not a medicine. It is a plant composed of over 400 different chemicals. The marijuana hemp plant has limited industrial uses and is not economically viable. The "Medical Marijuana" propaganda and the "Industrial Hemp" propaganda are just that -- propaganda. These are cleverly crafted strategies to circumvent Federal laws against the cultivation and distribution of marijuana and the United Nations treaties to which the U.S. is a signatory.

Joan Bellm, Illinois Drug Education Alliance, Board of Advisors, Drug Watch International, Board of Directors

January 8, 1997. As published in The Best of IDEA newsletter.

Return To The Affects Of Marijuana Index


 MARIJUANA UPDATE 1996 by Janet D. Lapey, M.D.

Marijuana causes many mental disorders, including acute toxic psychosis, panic attacks, flashbacks, delusions, depersonalisation, hallucinations, paranoia, depression, and "uncontrollable feelings of aggression." (1)

Increased aggressive behaviour after smoking marijuana has been reported in inner city males. (2)

Marijuana has long been known to trigger attacks of mental illness, such as bipolar (manic-depressive) psychosis and schizophrenia. It has been shown that marijuana users are six times more likely to develop schizophrenia than non-users. (3)

Marijuana use is associated with the development of Amotivational Syndrome. (4)

"Often the relationship of impairments and symptoms to marijuana use becomes evident only when the user is persuaded to stop, shows clear-cut improvement in mood and behaviour, and describes a feeling of coming out of a fog." (5)

Marijuana impairs perception, judgment, thinking, memory, and learning. Memory defects may persist six weeks after last use. (6)

Mental disorders caused by marijuana (cannabis) listed in the Diagnostic and Statistical Manual of Mental Disorders (DSM) IV, published by the American Psychiatric Association May 1994 include: Cannabis Dependence; Cannabis Abuse; Cannabis Intoxication (impaired motor coordination, anxiety, impaired judgment, sensation of slowed time, social withdrawal), often includes perceptual disturbances; Cannabis Intoxication Delerium (memory deficit, disorientation); Cannabis Induced Psychotic Disorder, Delusions; Cannabis Induced Psychotic Disorder, Hallucinations; Cannabis Induced Anxiety Disorder; other Cannabis-Related Disorders.

Marijuana causes both dependence and addiction. "Marijuana is an addictive drug...Addictive use is defined by compulsive, repeated use in spite of adverse consequences. Marijuanas effects include tolerance, leading to dependence, and then inability to cease use." (7)

In many parts of the country, there are more people admitted to drug treatment centers because of marijuana addiction than heroin addiction. (8)

A withdrawal syndrome occurs, consisting of "anxiety, depression, sleep and appetite disturbances, irritability, tremors, diaphoresis, nausea, muscle convulsions, and restlessness." (9)

Since marijuana impairs coordination, perception, and judgment, it is the cause of many accidents. A study of 1023 trauma victims revealed that marijuana had been used by 34.7%; alcohol had been used by 33.5%.(10)

This is similar to a 36.8% incidence of marijuana use reported in fatally injured drivers in California.(11)

A study of 182 fatal truck accidents revealed that 12.8% of the drivers had used marijuana, 12.5% alcohol, 8.5% cocaine, 7.9% stimulants. (12)

A roadside study of reckless drivers not believed to be impaired by alcohol found that 45% tested positive for marijuana. (13)

The effects of marijuana, which is fat-soluble, persist much longer than the effects of alcohol, which is water soluble. An experiment on pilots, using a computerised flight simulator, showed that their ability to land a plane was still impaired 24 hours after smoking a single marijuana cigarette. (14)

The use of marijuana during pregnancy is associated with babies of low birth weight. (15)

Also, there is evidence that such infants will show intellectual impairment a decade or more later. (16)

Children exposed to marijuana prenatally have increased behavioural problems; they have decreased visual perception, language comprehension, attention span and memory. (17)

Babies born to mothers who use marijuana during pregnancy have an eleven-fold increase in nonlymphoblastic leukemia. (18)

In males, marijuana diminishes testosterone production and lowers sperm counts. In females, marijuana disrupts hormone cycles. (19)

Studies have shown that marijuana is mutagenic and impairs DNA synthesis. (20)

Marijuana smoke produces airway injury, acute and chronic bronchitis, lung inflammation, and decreased pulmonary defenses against infection. Smoking one marijuana cigarette leads to airway deposition of four times as much cancer-causing tar as does tobacco smoke. (21)

Recently, there have been cases of cancer reported in young marijuana smokers, including cancer of the mouth, tongue, larynx, jaw, head, neck, and lungs. (22)

Marijuana causes impairment of the white blood cells which fight infections. (23)

Marijuana use decreases resistance to diseases such as herpes. (24)

Marijuana smokers have increased outpatient visits for respiratory illnesses, accidents, and other illnesses. (25)

The use of marijuana tends to lead to the use of other drugs. 20% of persons who use marijuana 3-10 times go on to use cocaine; 75% of persons who use marijuana 100 or more times go on to use cocaine. (26)

Non-marijuana users virtually never become cocaine users. In Alaska, when marijuana use was decriminalised, use by Alaskan youth of both marijuana and cocaine became the highest in the nation. The National Survey of High School Seniors showed that whereas nationally 17% of seniors had used marijuana in the past month, the Alaskan rate was 45%. The Alaskans then sensibly decriminalised marijuana use in 1990.

1. Schwartz RH. Pediatric Clinics of North America 34:305-317, 1987.
2. Cherek DR et al. Psychopharmacology 111:163-168, 1993.
3. Andreasson S et al. Lancet 2:1483-1485, 1987.
4. Schwartz RH, op.cit.
5. Jaffe JH. Drug Dependence. In Kaplan HI, Saddock BJ eds, Comprehensive Textbook of Psychiatry, Baltimore: Williams & Wilkins, 1989.
6. Schwartz RH et al. Am J Dis Child 143:1214-1219, 1989.
7. Gold MS. Marijuana, NY:Plenum Medical Book Co., p. 227, 1989.
8. Office of National Drug Control Policy. Pulse Check, December 1994.
9. Gold MS. op. cit. p. 103.
10. Soderstrom CA et al. Archives of Surg 123:733-737, 1988.
11. Williams AF et al. Public Health Report 100:19-25, 1985.
12. Department of Transportation. National Transportation Safety Board Report, Washington DC, February 5, 1990.
13. Brookoff D et al. New Eng J Med 331:518-522, 1994.
14. Leirer VO et al. Aviat Space Environ Med 62:221-227, 1991.
15. Zuckerman B et al. New Eng J Med 320:762-768, 1989.
16. Shalala DE. Say No to Legalization of Marijuana. The Wall Street Journal, August 18, 1995.
17. Fried PA. Life Sciences 56:2159-2168, 1995.
18. Robison LL et al. Cancer 63:1904-1910, 1989.
19. Gold MS. op. cit. p. 69-71.
20. Nahas G et al. Med J Austr 156:495-497, 1992.
21. Tashkin DP. West J Med 158:635-637, 1993.
22. Donald PJ Otolaryn Head & Neck Surg 94:517-521, 1986. Ferguson RP et al. JAMA 261:41-42, 1989. Taylor FM. South Med J 81:1213-1216, 1988. Donald PJ. Adv Exp Med Bio 288:33-46, 1991.
23. Spector S et al. Adv Exp Med Bio 288:47-56, 1991. Djeu J et al. Adv Exp Med Bio 288: 57-62, 1991. Watzl B et al. Adv Exp Med Bio 288: 63-70, 1991. Cabral GA et al. Adv Exp Med Bio 288: 93-105, 1991.
24. Cabral GA et al. Proc Soc Exp Bio Med 182:181-186, 1986.
25. Polen MR et al West J Med 158:596-601, 1993.
26. Kleber HD. J Clin Psych 49:2(Suppl), p. 3-6, 1988.

From Drug Watch International September 1996

Return To The Affects Of Marijuana Index


DO YOU KNOW THIS ABOUT MARIJUANA?


* * * Babies born to mothers who use marijuana during pregnancy have eleven times the risk of getting childhood leukemia. These children are the innocent victims of their parents marijuana use. Based on research by Dr. L. Robison in the publication Cancer and Dr. J. Buckley in Cannabis: Physiopathology, Epidemiology, Detection.

* * * Marijuana smoke produces airway injury, acute and chronic bronchitis, lung inflammation, and decreased pulmonary defences against infection. Smoking one marijuana cigarette leads to airway deposition of four times as much cancer-causing tar as does tobacco smoke. Based on research by Dr. D. Tashkin as reported in the Western Journal of Medicine.

* * * Cases of cancer, including cancer of the mouth, tongue, larynx, jaw, head, neck, and lungs have been reported in young
marijuana smokers that would not occur in tobacco smokers until much later in life. Based on research by reported in Otolaryngology, Head & Neck Surgery, the Journal of the American Medical Association and Southern Medical Journal.

* * * A 1995 study of blood samples taken from one thousand four hundred and forty-one dead or impaired drivers across Canada found marijuana present in 38% of these samples. Based on research by of Dr. Wayne Hindmarsh, Dean, Faculty of Pharmacy, University of Manitoba and Wayne Jeffery, R.C.M.P. Police Forensic Laboratory.

* * * Marijuana has long been known to trigger attacks of mental illness, such as bipolar (manic-depressive) psychosis and
schizophrenia. It has been shown that marijuana users are six times more likely to develop schizophrenia than are non-users. Based on research by of Dr. S. Andreasson published in Britain's The Lancet.

* * * The use of marijuana leads to the use of other drugs. Of those who use marijuana 3 to 10 times, 20% go on to use cocaine. Of those who use marijuana one hundred or more times, 75% go on to use cocaine. Based on research by as reported in the Journal of Clinical Psychiatry.

* * * Marijuana causes both dependence and addiction. Addictive use is defined by compulsive repeated use in spite of adverse consequences. Marijuana's effects include tolerance leading to dependence and inability to cease use. Based on research by of Dr. Mark Gold published in his book Marijuana.

* * * It's not just alcohol that caused impaired accidents. A roadside study of reckless drivers who were not impaired by
alcohol, showed that 45% of these drivers tested positive for marijuana. Based on research by of Dr. Dan Brookoff, published in the New England Journal of Medicine.

* * * The effects of marijuana persist much longer than the effects of alcohol. Using a computerised flight simulator, an experiment on pilots showed that their ability to land a plane was still impaired 24 hours after smoking one marijuana cigarette. Based on research by of Dr. V. Leirer in Aviation, Space & Environmental Medicine.

* * * Children exposed to marijuana prenatally have increased behavioural problems, and they have decreased visual perception, language comprehension, attention span and memory. These children are the innocent victims of their parents marijuana use. Based on research by of Dr. Peter Fried of the Ottawa Prenatal Prospective Study.

* * * In males marijuana use diminishes testosterone production and lowers sperm count. In females, marijuana use disrupts
hormone cycles. Marijuana is mutagenic, fetotoxic (poisonous to the foetus) and impairs RNA and DNA synthesis. Based on research by of Dr. Mark Gold in his book Marijuana and Drs. Latour and Nahas in the Medical Journal of Australia.

* * * Marijuana impairs the white blood cells which fight infection. Marijuana also causes decreased resistance to diseases such as herpes. Marijuana smokers have increased outpatient visits for respiratory illnesses, accidents and other illnesses. Based on research by of Drs. Spector, Djeu, Watzl and Cabral in Advances in Experimental Medicine & Biology and the Western Journal of Medicine.

* * * Children prenatally exposed to marijuana experienced more than two times the number of sleep arousals at night and
more awake time after each sleep arousal than children not prenatally exposed to marijuana. Based on research by published in The Archives of Pediatric and Adolescent Medicine.

* * * Cases of cancer from marijuana use are now well documented. In one California study 90% of young cancer patients are marijuana smokers compared with 40% of young people in California as a whole. Based on research by Dr. P. Donald in Otolaryngology, Head and Neck Surgery .

* * * HIV positive marijuana smokers have increased incidence of bacterial pneumonias in comparison to non-smokers. HIV positive smokers develop full-blown AIDS twice as fast as non-smokers. Based on research by in the journal, AIDS Weekly 1993, and Dr. Neiman, in the journal, AIDS 1993.

* * * In a survey of one hundred and fifty marijuana using students, 59% surveyed report they sometimes forget what a
conversation is about before it has ended. 41% report that if they read while stoned they remembered less of what they had read hours later. Based on research by of Dr. Richard Schwartz, Vienna Pediatric Associates in Psychiatric Annals.

* * * Long-term use of marijuana may cause irreversible memory problems. Marijuana users find it more difficult to separate
irrelevant information from the relevant, their reaction times are longer and electrical activity of the brain is slowed. Based on research by from Macquarie University, Sydney in conjunction with Australia's National Drug & Alcohol Research Centre.

* * * Marijuana impairs perception, judgment, thinking, memory and learning. Memory defects may persist for 6 weeks after last marijuana use. Based on research by of Dr. Richard Schwartz, Vienna Pediatrics Associates in the American Journal of Diseases of Children.

* * * There are significant negative effects of prenatal marijuana exposure on the performance of children in standard
intelligence tests. On average children exposed prenatally to marijuana will have a lower IQ compared to children who are not exposed. Based on research by of Dr. Day et al, in Neurotoxicology and Teratology.

* * * A cannabis (marijuana)-state-dependent effect in users includes weaknesses in analytic and synthetic skills. This includes
having difficulty sorting out information, synthesising and classifying information correctly and understanding subtle shades of meaning. Based on research by of Dr. Lundqvist in Life Sciences.

* * * Fetal Marijuana Symptoms are similar to Fetal Alcohol Syndrome are two diseases children are born with that are totally preventable. One of the leading specialists in cellular heredity, Dr. Akira Morishima of Columbia University, has said that in his 20 years of research on human cells he has never found any other drug, including heroin, which comes close to the DNA damage caused by marijuana.

* * * Saying nobody ever died from smoking marijuana is like saying nobody ever died from smoking tobacco. Marijuana contains the same cancer causing chemicals as tobacco. Marijuana contains acetone, hydrogen cyanide, ammonia, carbon monoxide, benzene, benzo pyrene, nitrosamines and many other cancer causing pollutants. Based on research by of G. Huber in Pharmacology Biochemistry and Behaviour.

* * * Who is really killing our rain forests? The United Nations reports that in Jamaica growers of marijuana plant their crops on isolated mountain slopes disturbing fragile forest soils. Growers clear cut and destroy the forests exposing fertile soil to runoff and erosion causing permanently damages forests.

* * * Marijuana causes many mental disorders, including acute toxic psychosis, panic attacks, flashbacks, delusions,
depersonalisation, hallucinations, paranoia, depression and "uncontrollable feelings of aggression". Based on research by of Dr. Richard Schwartz, Vienna Pediatrics Associates in Pediatric Clinics of North America.

Return To The Affects Of Marijuana Index


Lung cancer causing carcinogen more

prevalent in marijuana than in tobacco.


A breakthrough report published in the journal Science, October 18, 1996, provides the first true molecular evidence conclusively linking components in tobacco smoking to lung cancer. A chemical found in tobacco smoking, benzopyrene, causes genetic damage in lung cells that is identical to the damage observed in the DNA of most malignant tumors of the lungs.

Although scientists have been convinced in the past that smoking causes lung cancer, the strong statistical associations did not provide absolute proof. This paper absolutely pinpoints that mutations in lung cancer cells are caused by benzopyrene.

An average marijuana cigarette contains 30 nanograms of this carcinogen, compared to 21 nanograms in an average tobacco cigarette (Marijuana and Health, National Academy of Sciences, Institute of Medicine report, 1982).
This potent carcinogen suppresses a gene that controls growth of cells. When this gene is damaged, the body becomes more susceptible to cancer. This gene, P53, is related to half of all human cancers and as many as 70% of lung cancers.

Clearly marijuana smoke contains more of the potent carcinogen benzopyrene than tobacco smoke. Furthermore, the technique of smoking marijuana by inhaling deeply and holding the smoke within the lungs presents a chance of much greater exposure than a conventional tobacco cigarette.

* * * * * * * * * *

This material has been reviewed and commented on by William M. Bennett, M.D., Professor of Medicine, Division of Nephrology, Clinical Pharmacology and Hypertension at Oregon Health Sciences University, Portland, Oregon.

Dr. Bennett, who is listed in "BEST DOCTORS IN AMERICA," states, "The idea of using smoked marijuana containing these carcinogens as medicine, particularly for patients who have suppressed immune systems like those with AIDS, should
be unthinkable. Thus, prior to considering marijuana as medicine, one must abide by the old edict, "first do no harm."

Return To The Affects Of Marijuana Index


COMPARATIVE ANALYSIS OF MAINSTREAM SMOKE FROM
MARIJUANA AND TOBACCO REFERENCE CIGARETTE.

(Average weight: 1.110 mg; Length: 85 mm)

Measurements Marijuana Cigarette Tobacco Cigarette
Gas phase    
Carbon monoxide, vol.% 3.99 4.58
Carbon dioxide, vol.% 8.27 9.38
Ammonia, µg 228 199
HCN, µg 532 498
Cyanogen (CN)2, µg 19 20
Isoprene, µg 83 310
Acetaldehyde, µg 1,200 980
Acetone, µg 443 578
Acrolein, µg 92 85
Acetonitrile, µg 132 123
Benzene, µg 76 67
Toluene, µg 112 108
Vinyl chloride, ng* 5.4 12.4
Dimethylnitrosanline, ng* 75 84
Methylethylnitrosamine, ng* 27 30
Particulate phase    
Total particulate matter, dly, mg 22.7 39
Phenol, µg 76.8 138.5
O-Cresol, µg 17.9 24
m- and p- Cresol, µg 54.4 65
Dimethylphenol, µg 6.8 14.4
Catechol, µg 188 328
Cannabidiol, µg 190 -
Delta-9-tetrahydrocannabinol, µg 820 -
Cannabinol, µg 400 -
Nicotine, µg - 2,850
N-Nitrosonornicotine, ng* - 390
Naphthalene, µg 3 1.2
1-Methylnaphthalene, µg 6.1 3.65
2-Methylnaphthalene, µg 3.6 1.4
Benz(a)anthracene, ng* 75 43
Benzo(a)pyrene, ng* 31 21.1

* indicates known carcinogens.

From Marihuana and Health, National Academy of Sciences, Institute of Medicine
Report, Washington, D.C. 1982.

Return To The Affects Of Marijuana Index


HNN Press Release November 27, 1995

Cognitive dysfunctions in chronic cannabis users observed during treatment - an integrative approach


On December 8, Thomas Lundqvist will present a thesis in applied psychology at the University of Lund. The title of the thesis is 'Cognitive dysfunctions in chronic cannabis users observed during treatment - An integrative approach'.

Abstract: Clinicians report that chronic cannabis users seem to have symptoms, such as mental confusion and memory problems when entering treatment, that it is difficult to understand the cognitive style of chronic cannabis users, and that it is difficult to motivate them to submit to and keep them in treatment.

This is the incitement of the present thesis, which is based on clinical observations made during treatment of chronic cannabis users during and after a cessation of cannabis use over the past ten years. The systematized observations provide knowledge of how cannabis influences patients that submit to treatment. A treatment method is extensively described, based on the observations and the pharmacological knowledge of the cannabinoids. It is a strategy to help the patients in identifying the cognitive deficits and to help them in improvement and consolidation of the cognitive functioning.

A comprehensive description of the impact of cannabis on human cognitive functions is described in the conceptual framework of seven cognitive categories. The origin of the cognitive dysfunction is discussed in a context of biochemical, neuropsychological, and cognitive theory, as normalization of these cognitive functions during therapy with a cognitive
approach.

The thesis contains three studies. In the first study the observations, compiled since 1978, are presented according to the cognitive categories, which can be considered a logistic framework. The reversible process of the dysfunctional behaviour is the subject for the second study, describing the differences in thinking patterns between being a cannabis smoker and a
former cannabis smoker. In the third study chronic cannabis users were tested using the Sense of Coherence scale (SOC) to determine the extent to which patients display comprehensibility, manageability, and meaningfulness of life, which normalized between admission and the completion of therapy with a cognitive approach six weeks later. This is discussed in the context
of cognitive and psychosocial problems associated with chronic cannabis use.

It is concluded that the observed cognitive dysfunction is reversible.

Return To The Affects Of Marijuana Index


TOBACCO VS MARIJUANA


Our national leadership as well as the public is inflamed over recent reports of the tobacco industry increasing nicotine content in cigarettes, suppressing information about fire resistant cigarettes, and just generally being bad actors. Strangely, neither the public nor some members of Congress recognize the parallels to marijuana.

Tobacco is responsible for over 400,000 deaths every year from cancers, lung, heart and other vascular diseases. Marijuana has been linked to over 30% of vehicular trauma cases and is the most commonly abused illegal drug. It contains higher concentrations of cancer causing agents than tobacco.

Marijuana and tobacco cause at least the same amount of injury to the airways, pulmonary function, and lung immunity. Recent studies have demonstrated increased health care utilization among heavy marijuana smokers for respiratory problems.

Tobacco is addictive. Many physicians, including this writer, consider tobacco one of the hardest drugs to quit using. Marijuana is addictive, and is also one of the hardest drugs for addicts to quit. They often return to marijuana first if they relapse. The nicotine content of cigarettes varies. The major addictive ingredient in marijuana, THC, varies from 3%-29%.

Tobacco is associated with birth abnormalities. Marijuana is associated with decreased birth weight, length and shorter duration of pregnancy. Recent studies have demonstrated that young children exposed to marijuana during pregnancy have a ten-fold higher risk of developing acute non-lymphoblastic leukemia.

Patients frequently refuse to quit tobacco because it helps some of them lose weight and manage anxiety despite severe health consequences. A strong movement is supporting the use and legalization of smoked marijuana as medicine despite severe health consequences, toxicity, and the availability of safer more effective medications for the various medical problems. No
major medical organization would ever support tobacco as medicine. No major medical organization supports the use of smoked marijuana as medicine.

The tobacco lobby is a powerful, well financed and aggressive group that has successfully fought efforts to regulate, tax, or otherwise control it. The marijuana lobby is also well financed and organized. It continually floods the media and public with misinformation suggesting that marijuana is harmless and should be available medically and for general use via legalization of the drug. The drug culture "experts" downplay recent massive research showing health problems with marijuana. The tobacco "experts" deny the link of tobacco to cancer and other health problems.

Recently Rep Henry Waxman (D-CA) gave this admonition to the public:
``I wouldn't trust these so-called independent experts the tobacco industry has paraded out to the public and the Congress over the years to tell us things like tobacco smoking is really good for you because it relaxes you, or there is no connection between cigarette smoking and addiction, and of course their latest one that they don't manipulate the nicotine levels."

Congressman Waxman's admonition also applies to the current social atmosphere surrounding marijuana. We need to learn from the mistakes surrounding tobacco and not extend these mistakes to marijuana and other drugs. The one major reason that the health impact of marijuana and other illegal drugs is still less than tobacco is that the other drugs are still illegal. The drug culture and its lobbyists are every bit as insincere, manipulative, and self-serving as the tobacco lobby. Urge your local press and governmental leaders not to fall into another trap.

Eric A. Voth, M.D. FACP
Chairman, The International Drug Strategy Institute
Clinical Assistant Professor, Department of Medicine, University of Kansas,
School of Medicine

Return To The Affects Of Marijuana Index


MARIJUANA BRIEFS


Babies born to mothers who use marijuana during pregnancy have an eleven-fold increase in nonlymphoblastic leukemia. (Robison LL et al. Cancer 63:1904-1919, 1989)

In males, marijuana diminishes testosterone production and lowers sperm counts. In females, marijuana disrupts hormone cycles. (Gold MS. Marijuana, NY:Plenum Medical Book Co., p. 69-71)

Marijuana contains some of the highest cancer causing substances known. Marijuana contains carbon monoxide, carbon dioxide, acetone, benzene, toluene, vinyl chloride, dimethylnitrosamine, methylethylnitrosamine, benz(a)anthracene, benz(a)pyrene, ammonia, hydrogen cyanide, and many more. (Huber, Gary: Pharm.Biochem.Behavior Vol.40. P.630, 1991. National Academy of Sciences, Institute of Medicine report, Washington DC 1982, Marijuana & Health 1982)

Marijuana smoke produces airway injury, acute and chronic bronchitis, lung inflammation, and decreased pulmonary defences against infection. Smoking one marijuana cigarette leads to airway deposition of four times as much cancer-causing tar as does tobacco smoke. (Tashkin DP. West J Med 158:635-637, 1993)

Cases of cancer, including cancer of the mouth, tongue, larynx, jaw, head, neck, and lungs have been reported in young marijuana smokers. (Donald PJ Otolaryn Head & Neck Surg 94:517-521, 1986. Ferguson RP et al. JAMA 261:41-42, 1989. Taylor FM. South Med J 81:1213-1216, 1988, Donald PJ Adv Exp Med Bio 288:33-46, 1991)

Marijuana causes decreased resistance to diseases such as herpes. (Cabral GA et al. Proc Soc Exp Bio Med 182:181-186, 1986)

In a recent study of blood samples taken from 1441 impaired or dead drivers across Canada, marijuana was found in 38% of the samples. The study underestimates the drug use because in a number of cases, if alcohol were found, drug analyses may not have been done. (K. Wayne Hindmarsh, Dean, Faculty of Pharmacy, University of Manitoba, Wayne K. Jeffery, R.C.M.P. Police Forensic Lab)

Marijuana causes many mental disorders, including acute toxic psychosis, panic attacks, flashbacks, delusions, depersonalization, hallucinations, paranoia, depression and "uncontrollable hostility". (Jenike MA. Drug Abuse. In:Rubinstein E, Federman DD, eds, Scientific American Medicine, NY:Scientific American, Inc., 1993)

A roadside study of reckless drivers not believed to be impaired by alcohol found that 45% tested positive for marijuana. (Brookoff D et al. New Eng J Med 331:518-522, 1994)

Marijuana has long been known to trigger attacks of mental illness, such as bipolar (manic-depressive) psychosis and schizophrenia. It has been shown that marijuana users are six times more likely to develop schizophrenia than are non-users. (Andreasson S et al. Lancet 2:1483-1485, 1987)

Marijuana is a "gateway drug". Children who smoke pot are 85 times more likely to use cocaine than non marijuana users. (Joseph A. Califano, Jr., President of The Centre on Addiction and Substance Abuse)

Return To The Affects Of Marijuana Index

Information is supplied by the APFDFY Maryborough Qld Australia Phone/Fax 0741 233 810