Interpreting Your DNA Test Results for
Autosomal Recessive Disease … vWD Type 1

There are three possible test results: Clear, Carrier, and Affected. Below is a description of what each result means to you as a breeder.

CLEAR   This finding indicates that the gene is not present in your dog. Therefore, when used for breeding, a Clear dog will not pass on the disease gene.

CARRIER   This finding indicates that one copy of the disease gene is present in your dog, but that it will not exhibit disease symptoms. Carriers will not have medical problems as a result. Dogs with Carrier status can be enjoyed without the fear of developing medical problems but will pass on the disease gene 50% of the time.

AFFECTED   This finding indicates that two copies of the disease gene are present in the dog. These dogs always have a potential to bleed given the right circumstance and will always pass on the disease gene (mutation) to their progeny. Please see the following page,  for more detailed information. vWD Report  Also, inform your veterinarian and consult with him/her regarding this test result.

Breeding Strategies…

VetGen's DNA test findings can be extremely valuable when developing and implementing your breeding plans. The chart provided below outlines the implications of various breeding pair combinations. Remember, it is always best to breed "Clear to Clear". If followed by all breeders, these strategies will ensure a significant reduction in the frequency of the targeted disease gene in future generations of dogs. However, to maintain a large enough pool of good breeding stock, it may be necessary for some breeders to breed "Clear" to "Carriers" (see below).

Breeding Pair Combinations	CLEAR MALE	CARRIER MALE	AFFECTED MALE
CLEAR FEMALE	100% Clear	50/50 Carrier/Clear	100% Carrier
CARRIER FEMALE	50/50 Carrier/Clear	25/50/25 Clr./Carr./Affctd.	50/50 Carrier/Affected
AFFECTED FEMALE	100% Carrier	50/50 Carrier/Affected	100% Affected

Ideal Breeding Pair. Puppies will not have the disease gene (neither as Carrier nor as Affected).

Breeding Is Safe. No Affected puppies will be produced. However, some or all puppies will be Carriers. Accordingly, it is recommended that Carrier dogs which are desirable for breeding be bred with Clear dogs in the future, which will produce 50% carrier and 50% clear animals, to further reduce the disease gene frequency. These offspring should be tested by VetGen's test for this defective gene, and if possible, only the clear animals in this generation should be used.

High Risk Breeding. Some puppies are likely to be Carriers and some puppies are likely to be Affected. Even though it is possible that there will be some clear puppies when breeding "Carrier to Carrier", in general, neither this type of breeding pair nor "Carrier to Affected" are recommended for breeding.

Breeding Not Recommended. All puppies will be genetically Affected.

Canine: vWD Patents
US Patent No. 6,040,143 and 6,074,832
Licensed Exclusively by The Board of Regents of the
University of Michigan (Ann Arbor, MI) System to VetGen LLC
 

  Email: GenTest

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