I am one of those people who suffer chronic depression. Somewhat cyclic - over weeks I drift between ennui and chronic depression. I do have medication which takes the edge off the neuro-chemical side, but that is about all.
My life is largely empty. I spend most of my time in a state of acute ennui with absolutely no life direction. I live from short burst to short burst of motivation. I have no drives beyond the reptilian-based ones for hunger, warmth and sex and don't really enjoy any of those things so much as prefer the absence of the need-signals once the drive is - for the time - sated. Even the primate acquisitiveness is largely burned out: I occasionally get urges to shop, but they invariably end up in disappointment as I find nothing worth buying (that could, of course, be a function of modern commercial society and not wholly internal to me). I used to desire love, but either age or neglect has atrophied my emotions in that direction. I am cold, and I intellectually recognise the problem as existing but have no idea what to do about it. Or motivation to do anything anyway.
The bits of my brain that are supposed to make me want to cling to life at all costs seem to be dysfunctional, though I am not actually suicidal - while I can rationalise no adequate reason to bother living, nor can I see any reason not to, so I just keep going. I have no problem with death - though the life-death transition is something I would prefer to be quick. Death for me is just a state of not-being, and I have not-been before: the first 12.5 billion years of the universe before I was born didn't bother me at all, so I doubt the however-long of not-being after I am dead will either. I guess my ego might be a bit sub-normal too, since I have no problem with the concept of a universe without me in it and hence have no intrinsic need to invent an afterlife (or buy into a pre-packaged version of someone else's). Having an unusually acute grasp of the scale across space and time of the size of the universe relative to my own size and influence (and the size and influence of current humanity as a whole) probably doesn't help!
Some things that give me a short-term lift (though distraction might be a better word) are:
I also enjoy the company of friends, of course - both RL- and VR-side. Though I could count people I like being around on my fingers, I really enjoy their company.